top of page

Exploring Ketamine-Assisted Psychotherapy: What is Ketamine?


ketamine-assisted psychotherapy

This is the first post in our series exploring Ketamine-Assisted Psychotherapy (KAP), a cutting-edge approach to mental health treatment. Throughout this series, we’ll delve into the key aspects of KAP—from the science behind it to the crucial role of the therapist and what to expect during treatment. Whether you’re new to the concept or curious to learn more, this series will guide you through the transformative potential of ketamine in mental wellness.


In recent years, ketamine has quietly moved from the operating room to the therapist’s office, where it’s now reshaping the way we think about mental health treatment. Ketamine-Assisted Psychotherapy (KAP) is at the center of this shift. Long used as an anesthetic, ketamine is showing a remarkable ability to quickly alleviate symptoms of depression, anxiety, and PTSD—particularly in cases where traditional treatments have fallen short. 


What is Ketamine?


In the 1960s, scientists developed ketamine, a dissociative anesthetic that changed how doctors managed pain. Unlike older anesthetics that could dangerously slow down the body’s systems, ketamine blocked pain while keeping the heart and lungs working properly. This made it invaluable during the Vietnam War, where medics needed a fast, reliable way to treat soldiers under intense pressure.


Since then, ketamine has become a staple in modern medicine. But what makes it really stand out isn’t just its use in surgeries or emergencies—it’s how versatile it is. When it comes to treating chronic pain, especially in cases where other medications don’t work, ketamine often provides relief, helping people with conditions like fibromyalgia. Its ability to safely handle pain without major risks to breathing or heart function has cemented ketamine’s role in both human and veterinary care for decades.


What is Ketamine-Assisted Psychotherapy?


Ketamine-Assisted Psychotherapy represents a fascinating shift in the way we approach mental health treatment. It combines low-dose ketamine with traditional talk therapy, creating a unique space for patients to explore their emotions in a new light. What makes ketamine effective is its capacity to produce a dissociative state, allowing individuals to step back from their regular thought processes and address tough emotions or memories from a different point of view. Under the guidance of a therapist, this altered state becomes a tool for breakthroughs. Find more Therapy Collective of California tips and insights here.


How Ketamine Works in KAP


Ketamine works differently from most other psychiatric medications, which is why it’s gaining attention in mental health treatment. Its main action is on NMDA receptors in the brain, which are involved in controlling mood, memory, and how we perceive the world around us. By blocking these receptors, ketamine disrupts the brain’s usual patterns, creating an opportunity to reset some of the negative thought loops that are common in conditions like depression, anxiety, and PTSD. In Ketamine-Assisted Psychotherapy, this state allows patients to look at their emotions and experiences from a fresh, more detached perspective.


One of the most impressive things ketamine does is boost neuroplasticity—the brain’s ability to grow and change. Ketamine increases the release of glutamate, a key chemical in the brain, which then leads to more production of brain-derived neurotrophic factor (BDNF). BDNF helps the brain form new connections and pathways. This means that ketamine not only helps in the short term but also supports long-term healing by allowing the brain to rewire itself. For patients, this opens up new possibilities for breaking free from deeply ingrained patterns of thought and behavior.


Another major advantage of ketamine is how quickly it works. Unlike traditional antidepressants that can take weeks to have an effect, ketamine often lifts mood and reduces symptoms within hours. This makes it especially helpful for people experiencing severe depression or suicidal thoughts, providing quick relief and creating space for further therapeutic work. The fast improvement offers patients a much-needed break from their symptoms, allowing them to engage more deeply in therapy.


Integrating Insights for Lasting Change


The insights gained during a ketamine session are integrated into the patient’s ongoing therapy. After the session, a therapist helps the patient process their experience, making sense of any emotional breakthroughs or new perspectives. This integration work is key to making the effects of KAP last, as it helps patients apply what they’ve learned to their everyday lives, leading to long-term improvements in mood and mental health.


At Therapy Collective of California, our therapists are specially trained in Ketamine-Assisted Psychotherapy, ensuring that the insights gained during each session are skillfully integrated into your ongoing treatment. If you’re curious about KAP or think it might be a good fit for your mental health journey, we are here to provide more information and discuss how KAP could be integrated into your treatment plan. Find more Therapy Collective of California tips and insights here to better understand how KAP and other therapies can support your path to wellness.

bottom of page